When a giant alien spider escapes from a military lab and rampages across the city of Los Angeles, it is up to one clever exterminator and his security guard sidekick to kill the creature before the entire city is destroyed.

Decorated Vietnam hero, Frank Vega returns home only to get shunned by society leaving him without a job or his high school sweetheart. It's not until forty years later when an incident on a commuter bus makes him a local hero where he's suddenly celebrated once again. But his good fortune suddenly turns for the worse when his best friend is murdered and the police aren't doing anything about it.

Dave Lizewski is an unnoticed high school student and comic book fan who one day decides to become a super-hero, even though he has no powers, training or meaningful reason to do so.

Professional maids turn into amateurish thieves to steal a priceless painting from a mansion of a mafia lord.

After reuniting with Gwen Stacy, Brooklyn’s full-time, friendly neighborhood Spider-Man is catapulted across the Multiverse, where he encounters the Spider Society, a team of Spider-People charged with protecting the Multiverse’s very existence. But when the heroes clash on how to handle a new threat, Miles finds himself pitted against the other Spiders and must set out on his own to save those he loves most.

Miles Morales is now a fugitive on the run from every other Spider in the multiverse, and Gwen and his other friends might not be enough to help him.